The burden of CVD in Diabetic Patients in APAC

Prevalence of Cardiovascular Disease (CVD) among Type 2 diabetes mellitus (T2DM) patients1

T2DM is associated with a twofold increased risk of CVD vs non-T2DM patients1

Pre-Diabetic and Diabetic Patients at risk of Heart Failure

STAGE A

High risk for HF

  • Obesity
  • Hypertension
  • Hyperlipidemia
  • Diabetic Kidney Disease
  • Coronary Artery Disease
  • Sex
  • Social Determinants of Health
  • Duration of Diabetes
  • Uncontrolled Hypertension
STAGE B

Cardiac Structural Abnormality/ Dysfunction

  • LV systolic dysfunction
  • LV diastolic dysfunction
  • LV hypertrophy
  • Chamber enlargement
  • Valvular disease
  • Increased filling pressures OR Elevated biomarkers

Biomarkers

  • NT-proBNP (≥125 pg/mL)
  • BNP (≥50 pg/mL)
  • High Sensitive Cardiac Troponin
    (>99th per-centile upper reference limit)

Normal

Elevated

Repeat
in at least 1 year

Imaging
(CXR, Echocardiogram)

By utilising cardiac biomarkers, identifying high-risk and early-stage heart failure in patients with T2DM enables timely intervention to prevent or delay the advancement of heart failure.2